Dynamical Localization of DivL and PleC in the Asymmetric Division Cycle of Caulobacter crescentus: A Theoretical Investigation of Alternative Models
Fig 4
Following cytokinesis, PleC reverts to the phosphatase form.
(A) The total concentration of CckA (blue curve) remains constant during the cell cycle. However, the proportions of phosphatase (red curve) and kinase (green curve) forms of CckA change for each stage of the cell cycle. After cytokinesis (compartmentalization), the concentrations of the kinase and phosphatase fractions of CckA in the swarmer and stalked compartments (t = 120–150 min) are similar to their concentration in the non-compartmentalized swarmer (t = 0–30 min) and stalked cell stages (t = 30–90 min), respectively. (B) Spatiotemporal distribution of PleC kinase, DivK~P and CtrA~P after compartmentalization (at t = 120 min). Color indicates concentration gradients from minimum (blue) to maximum (red).