Inferring the Clonal Structure of Viral Populations from Time Series Sequencing
Fig 2
(A) A contrived evolution of a mixed viral population involving five mutations and six clones. Dotted lines indicate internal nodes extended to a leaf. (B) A notional representation of sequencing across the region of interest, and the resulting Depth-Position graph. Paired reads bridge two clusters of mutations. (C) Read count data obtained for the two clusters, with total depth x1000, along with artifacts †. (D) Evolutionary trees corresponding to (Ci,ii). (E) Ordered list of mutations and population prevalences (%). (F) Reconstruction of original tree in (A).