Exhaustive Analysis of a Genotype Space Comprising 1015 Central Carbon Metabolisms Reveals an Organization Conducive to Metabolic Innovation
Fig 5
Minimal distance between genotype networks.
Each rectangular colored area shows the color-coded minimal genotype distance Dmin between genotype networks comprised of metabolisms that are viable only on carbon sources indicated on the corresponding (x, y) positions where (n = 35). b) Average minimal distance among all pairs of genotype networks (red curve, inner vertical axis) and fraction of pairs of genotype networks that are neighbors (blue curve, outer vertical axis) as a function of metabolism size (n). c) Each rectangular area shows the color-coded average of the minimal distance Dmin (see color legend) between pairs of genotype networks with phenotypic complexity (k, x-axis) and (k’, y-axis) for metabolisms of size n = 35. At this size, the highest average minimal distances exists for metabolisms of complexity (k, k’) = (10, 7), which show Dmin = 2.6. d) Data points of a given shading indicate the distribution of genotypic distance DG (x-axis) among pairs of metabolisms with a given phenotypic distance DP, as indicated in the color legend for metabolisms of size n = 30.