A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity
Fig 8
Role of SOCS proteins in the differentiation and plasticity of the TSRN model.
The interactions mediated by SOCS proteins were removed to study their role. (A) Cell fate map of CD4+ T cell types when the SOCS protein interactions are removed from the TSRN model. The nodes represent CD4+ T cell types and the node sizes correspond to the size of the basin of attraction. New attractors corresponding to GATA3+IL9+IL10+ (Th2RTh9) and RORĪ³t+IL-10+ (Th17R) appeared. The edges represent transitions between cell types, the width of the edges corresponds to the number of times the transition occurred on logarithmic scale, and self-loops correspond to perturbations where the network returned to the original cell type. (B) Proportion of transitions between cell types in response to transient perturbations in the value of each node. On average, 21.65% of the perturbations result in transitions to another cell type, with 17.55% of perturbations of the intrinsic components of the network resulting in transitions, compared with 27.51% of perturbations of extrinsic cytokines.