A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity
Fig 7
Role of different network nodes in the plasticity of the TSRN model.
The proportion of transitions between attractors in response to transient perturbations in the value of each node. On average, 37.76% of the perturbations result in transitions to another cell type, with 47.12% of perturbations of intrinsic components resulting in transitions, compared with 24.43% of perturbations of extrinsic cytokines.