A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity
Fig 5
Cell fate map in response to the micro-environment and perturbations of the TSRN model.
The values of the extrinsic signals of the TSRN were fixed according to different polarizing micro-environments, and the resulting attractors were transiently perturbed. The nodes represent CD4+ T cell types, and the node sizes correspond to the size of the basin of attraction. The edges represent transitions between cell types, the width of the edges corresponds to the number of times the transition occurred in logarithmic scale, and self-loops correspond to perturbations where the network returned to the original cell type. The following micro-environments were studied: combinations of: (A) all extrinsic cytokines, (B) IFN-γe (Th1), (C)IL-4e and IL-2e (Th2), (D) IL-21e and TGF-βe (Th17), (E) TGF-βe and IL-2e (iTreg), (F) IL-10e (IL10), (G) IL-21e (Tfh), (H) IL-4e and TGF-βe (Th9), (I) no extrinsic cytokines (Th0).