A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity
Fig 4
Effect of the micro-environment on CD4+ T cell differentiation as determined using the TSRN model.
The values of the extrinsic signals of the TSRN were fixed according to different polarizing micro-environments. The basins of attraction of the resulting attractors were plotted on a logarithmic scale. The following micro-environments were studied: combinations of all extrinsic cytokines, no extrinsic cytokines (Th0), IFN-γe (Th1), IL-4e and IL-2e (Th2), IL-21e and TGF-βe (Th17), TGF-βe and IL-2e (iTreg), IL-10e (IL10), IL-21e (Tfh), and IL-4e and TGF-βe (Th9).