A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity
Fig 2
Minimal network of master transcriptional regulators CD4+ T (CD4+ T TRN).
Based on published experimental data we constructed a CD4+ T cell regulatory network that includes the master transcriptional regulators and the interactions among those regulators (CD4+ T TRN). (A) Graph of the CD4+ T TRN. Node colors correspond to cell types: Th1 (yellow), Th2 (green), Th17 (red), iTreg (blue) and Tfh (purple). Activations among elements are represented with black arrows and inhibitions with red dotted arrows. (B) Attractors of the CD4+ T TRN: Each column corresponds to an attractor. Each node can be active (green) or inactive (red). The attractors correspond to configurations that characterize the Th0, Th1, Th2, iTreg, T-bet+Foxp3+ and GATA3+Foxp3+ types. The attractors corresponding to the Th17 and Tfh types could not be recovered.