A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis
Fig 7
Model diagram showing receptor level treatment implementation.
The extracorporeal treatment introduces a trapped receptor state for CXCR-1/2. This state prevents IL-8 induced phenotype transition, which limits NK generation. The treatment is modeled entirely in the receptor level of model, leaving the systemic level (see Fig 1) unchanged.