Dissecting the Calcium-Induced Differentiation of Human Primary Keratinocytes Stem Cells by Integrative and Structural Network Analyses
Fig 2
Paralog analysis of dynamic genes.
(A) Known example from literature for opposite expression changes of paralogs involved in gap junction permeability [29]. (B) Statistics for correlated and anti-correlated dynamic and super-dynamic proteins. There are 950 highly co-expressed (r> = 0.6) dynamic paralogous pairs, 235 of which are super-dynamic and 281 highly anti-correlated (r< = -0.6) dynamic paralogous pairs, 19 of which are super-dynamic. (C) Example for correlated pairs (super dynamic), grouped by paralogous families. (D), (E), and (F): example for anti-correlated (super dynamic) grouped according to paralogous families. (G) Pfam domain differences between dynamic paralogous pairs. 281 anti-correlated paralogs (r< = -0.6) have a mean of 1.7 differences compared to 950 correlated paralogs (r> = 0.6) which have a mean difference of 1.28 in their domains (P = 0.009). The statistical significance was tested using Wilcoxon rank sum test.