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Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations

Fig 7

Distributions of helical substates of the wild-type p53-TAD and five cancer mutants, calculated from the last 80-ns of folding RE-GA simulations.

Contours are drawn 0.001, 0.002, 0.004, 0.008, 0.012, 0.024 and 0.048.

doi: https://doi.org/10.1371/journal.pcbi.1004247.g007