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Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations

Fig 6

Residue helicity profiles for the wild-type p53-TAD and five cancer mutants, derived from the last 80-ns segments of the RE-GA simulations.

Estimated uncertainties are similar for all profiles and only shown for the wild-type for clarity.

doi: https://doi.org/10.1371/journal.pcbi.1004247.g006