Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations
Fig 5
Comparison of theoretical (red traces) and experimental (black bars) PRE effects induced by four site-specific spin labels.
The theoretical profiles were calculated from the last 80-ns of the folding simulation of wild-type p53-TAD. The experimental profiles were extracted from the Supplementary Materials of Stancik et al. (2008) [43]. The correlation coefficient between the theoretical and experimental profiles is 0.5.