Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations
Fig 3
Probabilities of long-range contacts calculated from the last 80-ns segments of the folding (upper half) and control (lower half) RE-GA simulations.
Contours are drawn from 0.06 with an equidistant increment of 0.04. Residues are considered to be in contact if the minimal heavy atom distance is no greater than 4.2 Å. The correlation efficient of two contacts is 0.91 and the RMSD is 0.016.