Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations
Fig 2
A) Averaged residue helicity profiles calculated using different 80-ns segments of the control and folding RE-GA simulations of wild-type p53-TAD.
B) Probability distributions between termini and D21-K/N24 calculated from the last 80-ns of RE-GA simulations of the wild-type p53-TAD and two cancer-associated mutants. The inter-residue distances were calculated as the distances between corresponding CA atoms.