Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope Recognition
Fig 3
Geometry clusters of pMHC bound TCRs.
Pairwise Euler-angle distances (EAD) were determined for all pMHC-bound TCR structures according to Formula 1. The distance matrix was hierarchically clustered using the Ward update formula. We identified six significant clusters, using a bootstrapping approach [58]. Notably, in most of the cases, TCRs of the same type occur in the same cluster. Upper panel: Clustering dendrogram with bootstrapping results (au = approximately unbiased, bp = bootstrapping probability). Left panel: TCR types occurring within a cluster. Right/lower panel: PDB identifiers and corresponding TCR names. Central panel: Pairwise Euler-angle distances (EAD). The color key is provided in the bottom of the figure.