Synaptic Homeostasis and Restructuring across the Sleep-Wake Cycle
Fig 8
Canonical hippocampal-cortical model.
(A) Network model with an input layer, a principal neurons layer and an interneurons layer. (B) Input spikes shown for two different input cycles (top). Alternated memories are active in each cycle. Cells #1 to #100 belong to memory A and cells #101 to #200 belong to memory B. Postsynaptic spikes and Inhibitory Postsynaptic Potentials (IPSP) release shown following the above input (bottom). (C) Conductance of all synapses of two representative neurons during a full simulation run: one neuron whose memory selectivity remains stable after a sleep cycle (left); and one neuron whose memory selectivity is switched following the sleep cycle (right). (D) Population activity for all cycles with a specific memory on shown for two conditions of STDP modulation: (top) no Cp/Cd modulation during sleep leads to no change in the response pattern of the population; (bottom) high Cp/Cd modulation leads to complete restructuring of the response pattern of the population.