Existence and Control of Go/No-Go Decision Transition Threshold in the Striatum
Fig 8
DTT in striatum with symmetrical FSI projections.
(A) For the ‘additive’ input scenario, the striatum exhibits a DTT, in spite of the symmetrical feedforward inhibition from FSIs, refer to Eqs 15–17. A DTT is encountered not only along the diagonal (i.e increasing cortical excitation as well as feedforward inhibition from FSIs-dashed line), but also for clamped value of FSIs with increasing λCTX. (B) ΔMSN = Inpstr + Inpadd plotted for increasing values of λCTX. (C) ΔMSN = λD1 − λD2 as calculated from Eqs 2, 3. (D) In a ‘multiplicative’ input scenario, however, ΔMSN always remains positive for symmetrical FSI projections along the diagonal. A DTT can be imposed by clamping the FSI rates at a constant value, while increasing the cortical excitation. (E) ΔMSN = D1eff + D2eff + commeff plotted for increasing values of λCTX. (F) ΔMSN = λD1 − λD2 as calculated from Eqs 21, 22.