Accurate Encoding and Decoding by Single Cells: Amplitude Versus Frequency Modulation
Fig 4
The two regimes in the linear pathway model based on the master equation.
(A-B) fast (k+ c0 = 20s−1, k− = 100s−1, γ = 0.1s−1, α = 100s−1, ζ = 1) and (C-D) slow (k+ c0 = 0.01s−1, k− = 0.05s−1, γ = 1s−1, α = 25s−1, ζ = 500) switching. (A,C) Protein number as a function of time from Gillespie simulations for CM (blue lines) and BM (red lines). (B) The probability distribution for n target proteins is unimodal for both AM (blue) and FM (red). (D) The probability distribution is bimodal for AM (blue) and remains unimodal for BM (red) but with a long tail in the slow switching regime.