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Hi-C Chromatin Interaction Networks Predict Co-expression in the Mouse Cortex

Fig 2

Co-expressed genes are co-localized in 3D structure of the genome.

(A) Assessment of the enrichment of Hi-C interactions between strongly co-expressed gene-pairs compared to gene-pairs with no co-expression across different Hi-C resolutions. The y-axis indicates −log₁₀(p − value) of the one-tailed Wilcoxon rank-sum test used for the enrichment analysis. Hi-C interactions were mapped to genes using the MAX-mapping method. (B) Overview of the Hi-C resolution at which Hi-C interactions are most significantly associated with co-expressed gene-pairs for each chromosome. In each box, the horizontal line represents the median. The thick vertical line represents the interval of q₁ = 25^th and q₃ = 75^th percentiles. The thin vertical line represents the interval of q₃ + 1.5(q₃ − q₁) and q₁ − 1.5(q₃ − q₁).

doi: https://doi.org/10.1371/journal.pcbi.1004221.g002