Sharing and Specificity of Co-expression Networks across 35 Human Tissues
Fig 5
Genes linked to the blood-specific transcription factor GATA3 are enriched for immune function.
Blue circles (and links) denote tsTFs; red circles denote tsFXNGs; the color of a gene indicates its level of expression, with green denoting upregulation and red denoting downregulation. This tightly connected cluster of genes comprises the blood-specific TFs GATA3 and RUNX3 (circled in blue) and 11 genes with immune related function (circled in red). GATA3 has been previously linked to RUNX3 [53] and implicated as a master regulator of the immune system [54], required for the maintenance of T cells; consistent with this, the set of genes linked to GATA3 to is significantly enriched for the T cell receptor signaling pathway and the T cell receptor complex (Fisher’s exact test with Bonferroni correction p = .0001 and .01, respectively) with 8 of the top 10 most enriched functions for these genes relating to the immune system.