The Universal Statistical Distributions of the Affinity, Equilibrium Constants, Kinetics and Specificity in Biomolecular Recognition
Fig 2
Funneled energy landscape of the biomolecular binding.
Panel (A) shows the energy landscape of the receptor-ligand binding with a funneled shape towards the native state. Panel (B) shows the density of states of the ligand binding landscape. The intrinsic specificity ratio , where energy gap δE and energy roughness ΔE and size of the binding funnel measured by the entropy S are shown respectively. Panel (C) shows the free energy landscape of ligand binding, cartoon showing of receptor/ligand complex corresponds to the different binding states. The affinity measured by the free energy difference between the native binding state and unbound states are shown as ΔG. It can also be measured by the equilibrium constant K where ΔG = −RTlnK. Panel (D) shows the energy landscape and free energy profiles on different reaction coordinates.