A Power-Law Dependence of Bacterial Invasion on Mammalian Host Receptors
Fig 4
Host and pathogen specific power-law parameters.
(A) Mapping of 3-stage model parameters on power-law parameters. Each set of markers shows the effect of increasing a zipper model parameter over two orders of magnitude centered on a base value. Zipper model simulations were performed at MOI (500) and a power-law of the form P = Rβ/KDeff was fit to scaled output. Simulated data presented in S4C Fig (B) Power-law parameters for different hosts and bacterial strains. Mammalian cells were co-cultured with the indicated strain of GFP-expressing E. coli at 1000 MOI as described in (A). Raw data presented in S8D Fig