Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action
Fig 6
Common genes and a crosstalk subnetwork between T2D and cancer.
(A) The four-way Venn diagram summarizes the number of shared genes among the four gene sets with smallest P-value less than 0.05 in the T2D GWAS and the three types of cancer GWAS data sets (breast, pancreatic, prostate) in metformin-specific SPNetwork. (B) Degree comparison of common genes among the four gene sets in A, common genes’ direct interactors, and all genes in metformin-specific SPNetwork. (C) A crosstalk subnetwork of metformin action for T2D and cancer with three modules and enriched pathways. The legends for orange nodes, red nodes, and green nodes are same as in Fig 3. The nodes with underlines are key components in the metformin signal transduction process.