Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action
Fig 5
(A) Comparison of gene-level P-value distribution in T2D GWAS among three gene sets from the metformin-specific SPNetwork, human SPNetwork, and genes covered by T2D GWAS. (B) Interactions were extracted from metformin-specific SPNetwork. These interactions occur between T2D-related genes, namely, their smallest P-value less than 0.05 in T2D GWAS. The legends for orange nodes, red nodes, and green nodes are same as in Fig 3.