Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action
Fig 4
Functional comparison of the common genes, upstream network genes, and downstream network genes.
The common genes were those found in both metformin upstream network and downstream network. The upstream network genes were those only belonging to the metformin upstream network. The downstream network genes were those only belonging to the metformin downstream network. A) Proportion of genes of interest in Gene Ontology (GO) molecular function domain. B) Comparison of proportion of enriched pathway in the three gene sets at the first-level category of KEGG annotation. C) The clustering of enriched pathways for the three gene sets at second-level category of KEGG annotation.