The Role of Inhibition in a Computational Model of an Auditory Cortical Neuron during the Encoding of Temporal Information
Fig 5
Simulated non-synchronized neuron.
a. Classification of neuron-type [non-sync (o), sync (x), mixed (+), atypical (square)] across two parameters (Excitatory input and I/E ratio), with a fixed I-E delay of 0 ms. The two arrows indicate the parameters used for the simulated neurons in Fig. 5c (right arrow) and Fig. 5d (left arrow). b. Dependence of discharge rate ratio on net excitatory input (excitation-inhibition). Spearman correlation coefficient: r = 0.87, P<1.5 x 10-17 in simulated non-synchronized neurons. c-e. Examples of simulated and real non-synchronized neurons. Each plot is subdivided into a raster plot (left), IPI vs discharge rate plot (top right), and IPI vs vector strength plot (bottom right). The stimulus is played for 500 ms, which is indicated with the gray rectangle in the raster plot. The dashed line in the IPI vs discharge rate plot indicates a significant evoked response above the spontaneous rate (2σ). Error bars indicate SEM. c. Simulated neuron: I-E delay = 0 ms, E strength = 1.8 nS, I/E ratio = 1.3. d. Simulated neuron: I-E delay = 0 ms, E strength = 0.3 nS, I/E ratio = 0. e. Real neuron: (unit m32q3.1) from awake marmoset auditory cortex.