Non-linear Membrane Properties in Entorhinal Cortical Stellate Cells Reduce Modulation of Input-Output Responses by Voltage Fluctuations
Fig 2
Stellate cells express non-linear membrane properties that shape the voltage trajectory leading up to spike threshold.
(A) Average steady-state input resistance as a function of membrane voltage. Measures were taken in voltage-clamp using a 100 ms duration 5 mV step. (B) Average membrane voltage trajectory (grey lines indicate SEM) associated with approach from rest to first spike. For comparison, the exponential approximation using the membrane time constant measures taken at -75 mV is also shown. (C) Average membrane voltage trajectory (grey lines indicate SEM) associated with the interspike interval. (D) Representative example of an f-V curve from a stellate cell (solid line). Line indicates fit to a power-law function of the form shown in panel inset. Inset also shows box-plot of mean exponent (p) value for the power-law function fit.