Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations
Fig 6
Effects of lower selectivity of mitochondrial fusion and mitophagy.
Model simulations were performed by lowering the mitophagy selectivity (rD,max) and fusion selecitivity (rfusi,max) to half (50%) of the nominal values, for mutant mtDNA molecules (A) with RA (kR = 2) and (B) without RA. The error bars show the standard deviation of among 10,000 cells.