Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations
Fig 4
High selectivity in mitochondrial fusion and mitophagy providing efficient removal of mutant mDNA.
(A & B) Model simulations with high mitophagy selectivity (rD,max = 199) and non-selective fusion for (A) mutations without RA and (B) with RA (kR = 2). (C & D) Model simulations with high fusion selectivity (rfusi,max = 100%, rD,max = 5) for (C) mutations without RA and (D) with RA. The error bars represent the standard deviation of among 10,000 cells.