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Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations

Fig 2

Detailed model implementation.

(A) Partitioning of the 2D circular cell in the model. (B) OXPHOS defect function . (C) Schematic diagram of model implementation of mitochondrial turnover and fusion-fission (see text for detailed explanation). (D) Steady state distribution of mitochondrial nucleoid contents. The inset shows the fission propensity as a function of mitochondrial nucleoid content. (E) Nucleoids mixing time. Mitochondrial heterogeneity in each cell is represented by the mean coefficient of variation (COV) of R_M^mito. The mean COV of R_M^mito is scaled such that the steady state value is −100%. The results come from simulating only mitochondrial fusion-fission (without mitochondrial turnover) for 10,000 cells.

doi: https://doi.org/10.1371/journal.pcbi.1004183.g002