Interplay between Constraints, Objectives, and Optimality for Genome-Scale Stoichiometric Models
Fig 5
E.coli vertex cost follows a multimodal distribution.
For three growth conditions—aerobic (red, circle), aerobic restricted (purple, triangle), and anaerobic (blue, square)—we analyzed the vertex cost (PC) and vertex length (PL) of each vertex. Each dot in the main panel represents a vertex with a specific cost and length. Our results indicate that for E.coli the vertex length follows approximately a Gaussian-shaped distribution (dashed lines are Gaussian distributions with sample mean and sample standard deviation). Vertex cost follows a multimodal distribution; vertices are clustered in distinct groups with a specific cost. Due to file size limitations we only show a subset (10.000) of vertices for all conditions in the scatter plot.