Interplay between Constraints, Objectives, and Optimality for Genome-Scale Stoichiometric Models
Fig 3
Vertices correspond to optimal-yield EFMs or convex combinations of those EFMs.
Vertices correspond to optimal-yield EFMs (A) if they are restricted by one flux constraint and to a convex combination of EFMs if they are restricted by more than one flux constraint (B). Colors represent different flux values (red = 2, orange = 1.5, green = 1, and blue = 0.5). (A) visualization of EFM1, EFM2, and EFM3 (out of the twelve optimal-yield EFMs normalized to J18 = 1). Both EFM1 and EFM3 have a corresponding vertex with and without splitting, whereas EFM2 has only with splitting a corresponding vertex. (B) taking a convex combination of EFM1 and EFM2 or EFM1 and EFM3 (panel A) corresponds to a vertex when the constraints are J1 ≤ 2 and J15 ≤ 0.5.