Interplay between Constraints, Objectives, and Optimality for Genome-Scale Stoichiometric Models
Fig 1
Characterization of the optimal solution space of metabolic models.
The optimal solution space can be characterized by three topological features: vertices (purple), rays (green), and linealities (blue). Typically, optimal solution spaces of microbial genome-scale models are characterized by many vertices and only a few linealities and rays. Linealities do not exist when reversible reaction are split. Vertices can be described by a fixed active part (red) which is identical for each vertex and a variable part (orange), a few CoPE-FBA subnetworks [16]. We refer to S1 Fig. for examples of rays we found in the E.coli iAF1260 genome-scale metabolic model.