Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations
Fig 9
Mutation distributions of different Ras domain instances and the structure of Ras domain.
(A) bar graph shows Ras domains encoded by different genes have different mutation rates across cancer types. (B) heat map shows fraction of mutations observed at each residue of a given gene in a given cancer. (C) the structure of the Ras domain encoded by the KRAS gene (PDB structural model 4lpk[63]). GTP/GDP binding sites are displayed as magenta sticks, GDP binding sites are colored in cyan.