Loregic: A Method to Characterize the Cooperative Logic of Regulatory Factors
Fig 6
Promoter motifs for AND-consistent yeast triplets with directly and indirectly bound TFs.
We present two example yeast triplets, (RF1 is the TF YEL009C, RF2 is the TF YER040W, T is the gene YDL066W) at top and (RF1 is the TF YNL216W, RF2 is the TF YNL167C, T is the gene YHR033W) at bottom, both of which are consistent with the AND gate by Loregic. Both TFs in the top triplet have motifs in the target promoter region, but only one TF, YNL216W, in the bottom triplet has a motif in the target promoter region. The other TF, YNL167C, cooperates with YNL216W in an AND logical relation via protein-protein interaction.