Loregic: A Method to Characterize the Cooperative Logic of Regulatory Factors
Fig 3
Cooperative logics found by Loregic for yeast regulatory triples.
A—Loregic gives for each triplet a matched logic gate as shown in the table. The bar plot shows the distribution of 4126 gate-consistent TF-TF-target triplets across matched logic gates. The symmetric gate pairs are marked using diamonds on top of bars with identical superscript numbers due to randomly assigning TFs as TF1 or TF2. B—Top: an example RF pair (RF1 is YML113W, RF2 is YBR083W) with “homogenous” gate-consistent triplets—matching the same, logic gate across all targets; middle: an example RF pair (RF1 is YKL015W, RF2 is YKL032C) with “inhomogeneous” gate-consistent triplets—matching different logic gates across all targets; and bottom: an example RF pair (RF1 is YMR037C, RF2 is YOR344C) with non-gate-consistent triplets, i.e. triplets inconsistent with all logic gates across all targets.