Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies
Fig 8
Interpreting the integrated model in the context of platelet signaling pathways.
As in Fig. 7, activatory synergies are represented by green lines, inhibitory synergies by red lines. Activators U46619 (Xa), TRAP (Ta), Epinephrine (Ea) ADP (Aa) and CRP (Ca) are indicated extracellularly, acting on their receptors, namely the thromboxane receptor (TXA2R), the thrombin receptor (PAR1), the Epinephrine receptor (α2AR), the ADP receptors (P2Y12, P2Y1 and P2X), and the collagen receptor (GPVI).