Intra-Tumour Signalling Entropy Determines Clinical Outcome in Breast and Lung Cancer
Fig 3
Prognostic implications of signalling entropy in lung adenocarcinoma.
A) The plots display the concordance index for signalling entropy in each data set alongside its 95% confidence interval. The overall concordance index was derived via meta-analysis using a random effects model. The vertical line denotes concordance index = 0.5, data sets where the confidence interval for the concordance index crosses this line did not reach significance. Meta-analysis of signalling entropy across 7 lung adenocarcinoma data sets reveals that our measure is significantly prognostic across all samples and within the stage I stratum. B) The plots display the negative of the log10 of the p-value for a survival analysis using Cox-regression on 3-year censored data, evaluating the prognostic significance of signalling entropy and tumour stage in each data set. The overall p-value was produced by a Fisher’s combined test. The vertical red line on each plot denotes p = 0.05; data sets in which the bar crosses this line reached significance for the corresponding score. Meta-analysis comparison of signalling entropy with pathological tumour stage across 7 lung adenocarcinoma data sets, demonstrates that signalling entropy outperforms the stage Ia/b sub staging across stage I samples.