The Molecular Clock of Neutral Evolution Can Be Accelerated or Slowed by Asymmetric Spatial Structure
Fig 2
For spatial structures with symmetry, K = u.
(a) For a well-mixed population, represented by a complete graph with uniform edge weights, a neutral mutation has a 1/N chance of fixation, where N is the population size. It follows that the rate K of neutral substitution in the population equals the rate u of neutral mutation in individuals. (b) The same result holds for spatial structures in which each site is a priori identical, such as the cycle with uniform edge weights.