Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms
Fig 6
Focal adhesion as a central hub for targeting host cells.
The number of shared protein-protein interactions (PPIs) targeted by B. mallei virulence factors is shown as lines proportional to the number of PPIs (only connections with 10 or more interactions are illustrated). Physiological, cancer, and disease pathways were all interconnected via signaling pathways that could be affected through the focal adhesion pathway.