Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms
Fig 4
Actin cytoskeleton organization as a virulence factor target.
Human proteins targeted by B. mallei proteins formed an interaction module that was primarily linked to cytoskeleton organization and focal adhesion. Twenty-five of these proteins were involved in cytoskeleton organization processes; 13 of them (red stars) interacted with each other (forming an interaction module), and the remaining 12 proteins (dark red circles) were on average < 2 nodes (< 3 edges) away from the interaction module. The figure also shows the overlap between the cytoskeleton organization interaction module and the focal adhesion pathway (shaded area), where connecting protein interactions from focal adhesion pathway proteins or other proteins appear as smaller circles and dashed lines. Note that all human proteins shown interacted with one or more B. mallei proteins.