Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms
Fig 2
Clustering of human proteins targeted by B. mallei known virulence factors.
The graphic shows 116 proteins of the largest connected component of the human PPI network that belong to one or more statistically significant interaction modules. Note that each of these human proteins also interacted with one or more known B. mallei virulence factors. As exemplified by the annotated interaction modules in A-F, the known virulence factors targeted human proteins that were highly interacting among themselves and belonged to the same biological process. For a list of host proteins that compose each interaction module, see S2 Table.