The Interaction between Seasonality and Pulsed Interventions against Malaria in Their Effects on the Reproduction Number
Figure 8
Effect size of a pre-erythrocytic vaccine.
The lines labelled “Approx.” are approximate effect sizes calculated using the mean efficacy over the cycle between vaccination campaigns. The lines labelled “Moderate efficacy” have 50% initial efficacy and 80% coverage, while “High efficacy” means 90% initial efficacy and 90% coverage. A: Vaccination every three years (triennial) in a non-seasonal setting, with varying duration of protection. B: Annual vaccination with a one year half-life or triennial vaccination with a three year half-life (so the mean efficacy is the same in both cases), with a three-month high season and varying time of vaccination. Annual vaccination with a high efficacy transmission-blocking vaccine (TBV) is also shown.