System Model Network for Adipose Tissue Signatures Related to Weight Changes in Response to Calorie Restriction and Subsequent Weight Maintenance
Figure 2
Workflow of the network analysis.
Intra- and inter-omics networks were first inferred separately before a global merging for each time step: at baseline, after a 8-week low calorie diet and after weight maintenance diet (3 groups). Node clustering was then performed and clusters were systematically analyzed with most important nodes extraction and across time comparison. Resulting products of each step are given in purple and significant tests to assess the validity of the approach are given in yellow.