A Computational Approach to Identifying Gene-microRNA Modules in Cancer
Figure 5
Network presentation of module 22 in ovarian cancer.
In this network, diamonds represent miRNAs: sky-blue nodes for ovarian cancer miRNAs from the HMDD database, pink nodes for ovarian cancer miRNAs supported by the literature, and yellow nodes for the remaining miRNAs. Genes are represented by circles: pink nodes for ovarian cancer genes validated by the literature, green nodes for ovarian cancer genes validated by the DDOC database, orange nodes for cancer genes, and white nodes for the remaining genes. A blue solid line indicates that the MCC value between a gene and a miRNA is larger than 0.3. A purple line indicates that the linked genes are enriched together with at least one function. For example, COL6A1, COL5A3, THBS2, FN1, COL1A1, COL5A1, COLA1A, and COL3A1 are enriched with at least one function together (ECM receptor pathway or Focal adhesion pathway). Table S17 presents PubMed identifiers for ovarian cancer genes in pink nodes.