The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences
Figure 5
Different experimental data can be explained at different activity regions; effects are robust to underlying distributions or parameter changes.
(A) The 95% confidence regions for experimental data from different cortical layers ([10, 36, 37], Fig. 1A) are located at different activities for different layers. Confidence regions for same experimental location (layer II) overlay. (B) The 95% confidence regions, which emerge from the same model parameters when using a distribution of potential synapses from [40], are qualitatively not different. (C), Schematic drawing which summarises the influence of a and ρ on the location of the confidence region (see (E) and (F)). For the layer IV data, we evaluated how (D) the area in activity space, (E) the average presynaptic activity, and (F) the average postsynaptic influence of the activity confidence region changes for different structural plasticity parameters a and ρ. (Parameters BCM rule with synaptic scaling with θ = 0.08, vtss = 0.1, κ = 9.0, structural plasticity: P = 12, ln pbuild = −16, in A-C: a = 2.0, ρ = 0.125)