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The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences

Figure 4

Model can account for experimental data for suitable pre- and postsynaptic activities.

(A) The probability distribution of the number of synapses between two neurons from experiment ([36], red) is similar to the distribution resulting from the proposed model (blue) at vj = 0.656 and vi(S = 0) = 0.2975. (B) The activity confidence regions, where error of the experimental outcome lies within the most probable 95% (yellow) or 66% (green) of the trials, when randomly sampling from model distribution, spans over a broad range of activities. (C) Colour code shows the Monte-Carlo p-values for the hypothesis that experimental data comes from model distribution. For comparability, postsynaptic influence I was transformed to the postsynaptic activity for S = 0 in all figures. (Parameters: BCM rule with synaptic scaling with θ = 0.08, vtss = 0.1, κ = 9.0, structural plasticity: P = 12, ln pbuild = −16, a = 2.0, ρ = 0.125)

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1004031.g004