Analysis of Individual Protein Regions Provides Novel Insights on Cancer Pharmacogenomics
Figure 2
Perturbations of different regions in the same protein can have different drug effects.
(a) Missense mutations in different PFRs of MSH6 lead to increased sensitivity towards three different drugs: AEW541, RAF5 and Lapatinib. The protein level analysis on the other hand reveals a potential association with Erlotinib (shown in blue). This highlights the complementarity between protein and PFR-centric approaches.