The Thalidomide-Binding Domain of Cereblon Defines the CULT Domain Family and Is a New Member of the β-Tent Fold
Figure 8
Comparison of the substrate-binding sites in CULT and MsrB.
The superimposition shows the thalidomide binding sites in the CULT domain structures (M. gryphiswaldense MGR_0879, G. gallus 4CI2, M. musculus 4TZC) in gray and the methionine sulfoxide binding site of MsrB (X. campestris 3HCI) in red. The ligands are colored cyan (thalidomide) and marine blue ((2S)-2-(acetylamino)-N-methyl-4-[(R)-methylsulfinyl]butanamide). Residue numbers are provided for the M. gryphiswaldense structure in gray, and for MsrB in red.